PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G13290.1
Common NameDOT5, T6J4.5, WIP6
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family C2H2
Protein Properties Length: 302aa    MW: 34346.8 Da    PI: 6.9384
Description C2H2-like zinc finger protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G13290.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H216.32.7e-05101120120
                  EEETTTTEEESSHHHHHHHH CS
      zf-C2H2   1 ykCpdCgksFsrksnLkrHi 20 
                  ++C+ C+k+F+r  n++ H+
  AT1G13290.1 101 FSCSVCNKTFNRFNNMQMHM 120
                  89*****************9 PP

2zf-C2H2110.0014186209123
                  EEET.TTTEEESSHHHHHHHHHHT CS
      zf-C2H2   1 ykCp.dCgksFsrksnLkrHirtH 23 
                  ++C  +C k+F  + + ++H +++
  AT1G13290.1 186 FRCRkKCEKTFAVRGDWRTHEKNC 209
                  89******************9987 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576672.54E-597122No hitNo description
Gene3DG3DSA:3.30.160.609.6E-6101120IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profilePS5015710.263101128IPR007087Zinc finger, C2H2
PROSITE patternPS000280103123IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.602.3E-4172207IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010087Biological Processphloem or xylem histogenesis
GO:0010305Biological Processleaf vascular tissue pattern formation
GO:0010588Biological Processcotyledon vascular tissue pattern formation
GO:0048364Biological Processroot development
GO:0005634Cellular Componentnucleus
GO:0003676Molecular Functionnucleic acid binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0009009anatomyplant embryo
PO:0009010anatomyseed
PO:0009031anatomysepal
PO:0009032anatomypetal
PO:0009046anatomyflower
PO:0009052anatomyflower pedicel
PO:0025022anatomycollective leaf structure
PO:0001078developmental stageplant embryo cotyledonary stage
PO:0001081developmental stagemature plant embryo stage
PO:0004507developmental stageplant embryo bilateral stage
PO:0007611developmental stagepetal differentiation and expansion stage
PO:0007616developmental stageflowering stage
Sequence ? help Back to Top
Protein Sequence    Length: 302 aa     Download sequence    Send to blast
MYNNNQYSFS GDEDSVVLSL GPPGQQYPSH NKPTSTKPSS DHEFNHPLTN PNGVTVALHI  60
GPPSSDKETL SGGNNQEGLT ARQGQYWIPS LSQILVGPTQ FSCSVCNKTF NRFNNMQMHM  120
WGHGSQYRKG PESLRGTKSS SSILRLPCYC CAEGCKNNID HPRSKPLKDF RTLQTHYKRK  180
HGAKPFRCRK KCEKTFAVRG DWRTHEKNCG KLWFCVCGSD FKHKRSLKDH VRAFGDGHAA  240
HTVSDRVVGI GDADEDDEEE EEEEEDDVEE EDAHEENVRG EKNYGIRYDH FRRYGQISDD  300
NY
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO306832090.0
Genevisible257515_at0.0
Expression AtlasAT1G13290-
AtGenExpressAT1G13290-
ATTED-IIAT1G13290-
Functional Description ? help Back to Top
Source Description
TAIREncodes a putative zinc finger protein (C2H2 family, type IIIA, subclass A1d) that has a WIP domain. Seedlings with mutations in DOT5 have a misaligned venation defect in their leaves and cotyledons. Additional developmental abnormalities, such as elongated petioles and aberrant phyllotaxy suggest that DOT5 is required for normal shoot and root development.
UniProtProbable transcriptional regulator (Probable). Involved in leaf vasculature patterning (PubMed:18643975). {ECO:0000269|PubMed:18643975, ECO:0000305|PubMed:20541552}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G13290.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Phenotype -- Disruption Phenotype ? help Back to Top
Source Description
UniProtDISRUPTION PHENOTYPE: Defects in venation pattern in leaves and cotyledons, altered phyllotaxy of vegetative leaves, short roots, delay in leaf initiation and reduced apical dominance. {ECO:0000269|PubMed:18643975}.
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G13290
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAJ3118090.0AJ311809.1 Arabidopsis thaliana mRNA for WIP6 protein (At1g13290 gene).
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_172787.10.0protein DOT5
SwissprotQ9FX680.0ZWIP6_ARATH; Zinc finger protein WIP6
TrEMBLD7KQE10.0D7KQE1_ARALL; Zinc finger family protein
STRINGAT1G13290.10.0(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM23928237
Representative plantOGRP4101597
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Sagasser M,Lu GH,Hahlbrock K,Weisshaar B
    A. thaliana TRANSPARENT TESTA 1 is involved in seed coat development and defines the WIP subfamily of plant zinc finger proteins.
    Genes Dev., 2002. 16(1): p. 138-49
    [PMID:11782451]
  3. Englbrecht CC,Schoof H,B
    Conservation, diversification and expansion of C2H2 zinc finger proteins in the Arabidopsis thaliana genome.
    BMC Genomics, 2004. 5(1): p. 39
    [PMID:15236668]
  4. Petricka JJ,Clay NK,Nelson TM
    Vein patterning screens and the defectively organized tributaries mutants in Arabidopsis thaliana.
    Plant J., 2008. 56(2): p. 251-63
    [PMID:18643975]
  5. Appelhagen I, et al.
    Weird fingers: functional analysis of WIP domain proteins.
    FEBS Lett., 2010. 584(14): p. 3116-22
    [PMID:20541552]
  6. Terryn N, et al.
    Sequence analysis of a 40-kb Arabidopsis thaliana genomic region located at the top of chromosome 1.
    Gene, 1998. 215(1): p. 11-7
    [PMID:9666060]